Plasticity of NMDA receptor-mediated excitatory postsynaptic currents at perforant path inputs to dendrite-targeting interneurons
نویسندگان
چکیده
منابع مشابه
Effects of Ketamine on Neuronal Spontaneous Excitatory Postsynaptic Currents and Miniature Excitatory Postsynaptic Currents in the Somatosensory Cortex of Rats
Background: Ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. The mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown. We aimed to elucidate the effects of different concentrations of ketamine on the glutamatergic synaptic transmission of the neurons in the primary somatosensory cortex b...
متن کاملeffects of ketamine on neuronal spontaneous excitatory postsynaptic currents and miniature excitatory postsynaptic currents in the somatosensory cortex of rats
background: ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. the mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown. we aimed to elucidate the effects of different concentrations of ketamine on the glutamatergic synaptic transmission of the neurons in the primary somatosensory cortex b...
متن کاملPostnatal developmental alterations in the locus coeruleus neuronal fast excitatory postsynaptic currents mediated by ionotropic glutamate receptors of rat
Introduction: In the present work, spontaneous postsynaptic currents were assessed to investigate the postnatal development of excitatory postsynaptic currents in locus coeruleus neurons. Methods: In this study, AMPA and NMDA receptor-mediated spontaneous synaptic currents in the neurons of locus coeruleus were assessed using whole cell voltage-clamp recording during the first three weeks. ...
متن کاملNMDA receptor - mediated modulation of excitatory 1
28 29 Activity of neurons in the dorsal motor nucleus of the vagus nerve (DMV) is 30 closely regulated by synaptic input, and regulation of that input by glutamate receptors 31 on presynaptic terminals has been proposed. Presynaptic NMDA receptors have been 32 identified in a number of brain regions and act to modulate neurotransmitter release, but 33 functional presynaptic NMDA receptors have ...
متن کاملCoincidence detection of convergent perforant path and mossy fibre inputs by CA3 interneurons.
We performed whole-cell recordings from CA3 s. radiatum (R) and s. lacunosum-moleculare (L-M) interneurons in hippocampal slices to examine the temporal aspects of summation of converging perforant path (PP) and mossy fibre (MF) inputs. PP EPSPs were evoked from the s. lacunosum-moleculare in area CA1. MF EPSPs were evoked from the medial extent of the suprapyramidal blade of the dentate gyrus....
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2012
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2012.234740